ArticleFrontiers in immunology2025
Negative associations of age and lifestyle factors with the antibody response to the COVID-19 vaccine BNT162b2 in health workers from Spain.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
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Abstract
Introduction: Despite the high efficacy of the anti-coronavirus disease 2019 (COVID-19) BNT162b2 vaccine (Comirnaty Methodology: We studied the determinants of the humoral response to the anti-COVID-19 vaccine BNT162b2 in 200 healthcare workers followed up for 2 years. Serum samples were tested for the anti-spike immunoglobulin G (IgG) levels and neutralizing antibody titers against selected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants at different time points after primary and booster vaccinations. Anthropometric data and clinical and lifestyle information were also collected. Statistical analyses consisted of linear and logistical regressions for point estimations and the Mann-Whitney, Friedman, and generalized estimating equations for repeated measures. Results: After the primary vaccination, the antibody titers and the percentage of seroconverted individuals peaked at 5 weeks but declined after 1 year; however, they remained high after the booster administration. After the first dose of the vaccine, negative associations of the anti-spike IgG levels with age ( Conclusion: Lifestyle habits and age had an association with the humoral response to the BNT162b2 vaccine.
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