Evidence mapPaperPMID 40520013Full record

ArticleInternational journal of biological sciences2025

Radio-chemotherapy and metformin selectively modulate the heterogeneous landscape of glioma with ribosome biogenesis, long non coding RNA and immune-escape markers as major player.

Silvia Valtorta, Silvia Granata, Stefano de Pretis, Gloria Bertoli, Serena Redaelli, Valeria Berno, Antonello E Spinelli, Santo Diprima, Paolo Rainone, Angela Coliva and 7 more

Abstract read
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Silvia ValtortaInstitute of Bioimaging and Complex Biological Systems (IBSBC), National Research Council (CNR), 20054 Segrate (MI), Italy.
Silvia GranataNuclear Medicine Department, San Raffaele Scientific Institute (IRCCS), 20312 Milan, Italy.
Stefano de PretisCenter for Omics Sciences, San Raffaele Scientific Institute (IRCCS), 20132 Milan, Italy.
Gloria BertoliInstitute of Bioimaging and Complex Biological Systems (IBSBC), National Research Council (CNR), 20054 Segrate (MI), Italy.
Serena RedaelliSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Valeria BernoAdvanced Light and Electron Microscopy Bioimaging Center ALEMBIC, San Raffaele Scientific Institute (IRCCS), 20132 Milan, Italy.
Antonello E SpinelliExperimental Imaging Center, San Raffaele Scientific Institute (IRCCS), 20132 Milan, Italy.
Santo DiprimaCenter for Omics Sciences, San Raffaele Scientific Institute (IRCCS), 20132 Milan, Italy.
Paolo RainoneInstitute of Bioimaging and Complex Biological Systems (IBSBC), National Research Council (CNR), 20054 Segrate (MI), Italy.
Angela ColivaNuclear Medicine Department, San Raffaele Scientific Institute (IRCCS), 20312 Milan, Italy.
Sergio ToddeSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Giovanni MarfiaLaboratory of Experimental Neurosurgery and Cell Therapy, Unit of Neurosurgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Stefania NavoneLaboratory of Experimental Neurosurgery and Cell Therapy, Unit of Neurosurgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Manuela CaroliLaboratory of Experimental Neurosurgery and Cell Therapy, Unit of Neurosurgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Angela BentivegnaGBM-BI-TRACE (GlioBlastoMa-BIcocca-TRAnslational-CEnter), University of Milano-Bicocca, 20900 Monza, Italy.
Nadia Di MuzioDepartment of Radiation Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Rosa Maria MorescoInstitute of Bioimaging and Complex Biological Systems (IBSBC), National Research Council (CNR), 20054 Segrate (MI), Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a short survival time after standard therapy administration including radiotherapy (RT) associated with temozolomide (TMZ). Here, we investigated the effects of radiochemotherapy in association with metformin (MET), a drug targeting cell metabolism on a syngeneic GBM mouse model using Positron Emission Tomography imaging with [

Indexed as

Brain NeoplasmsGlioblastomaGliomaMetforminRibosomesRNA, Long NoncodingAnimalsCell Line, TumorChemoradiotherapyHumansMiceMice, Inbred C57BLTemozolomideTumor MicroenvironmentMetforminRNA, Long NoncodingTemozolomideGlioblastomaLAG3long-non coding RNAmetforminPET imagingradio-chemotherapysingle-cell RNA sequencing

Identifiers

PMID40520013
PMCPMC12160513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.