ArticleInternational journal of preventive medicine2025
The Effect of Multimodal Exercise on the Levels of BDNF and GDNF in Patients with Parkinson's Disease.
Article in International journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Targeting GPCR Signaling in Parkinson's Disease: From Molecular Pathology to Exercise-Based Therapeutics.Molecular neurobiology · 2026Review
- Exercise for Non-Motor Symptoms of Parkinson's Disease: An Evidence-Based Review of Clinical Trials, Dosing Considerations, and Mechanistic Insights.Neural plasticity · 2026Review
- Break free from cognitive impairment: The magic of exercise-induced molecules.Brain, behavior, & immunity - health · 2025Review
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Authors and funding
5 authors.
Funding
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Abstract
Background: Parkinson's disease (PD) leads to a significant decrease in brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). This study explores the effect of 12 weeks of multimodal exercise on the levels of BDNF and GDNF in patients with PD. Methods: The study is a quasiexperimental study with random sampling. It was conducted in 2024 at Isfahan. Demographic data were collected using the demographic questionnaire outlined in the Methods section. Thirty patients were randomly divided into two equal groups of multimodal exercise and control, with no significant differences in age, weight, and height. The variables of BDNF and GDNF were assessed in pre- and post-tests. Multimodal exercise was performed 5 days a week for 12 weeks. Data were analyzed using covariance and Results: The study observed significant differences in BDNF and GDNF, among two groups of PD ( Conclusions: Given that multimodal exercises are effective in increasing BDNF and GDNF in individuals with PD, it is recommended to incorporate the benefits of these exercises into physical rehabilitation programs. Therefore, the combined approach of multimodal exercises (resistance, aerobic, and balance) is recommended as the most effective complementary therapeutic strategy for PD.
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Registered trials
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