ArticleFrontiers in pharmacology2025
Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Background: Prostaglandins play a vital role as crucial metabolites and inflammatory indicators within the arachidonic acid (AA) metabolic pathway. Conventional assays typically focus on a single inflammatory indicator, while multi-index detection entails a large number of samples. Methods: In this study, an ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QQQ-MS/MS) method was newly developed for simultaneous quantitative analysis of nine AA metabolites, including prostaglandin F2β (PGF Results: The newly established UHPLC-QQQ-MS/MS method successfully and rapidly quantified the contents of the nine prostaglandins simultaneously. The methodology was validated. The levels of PGE Conclusion: The method established in this study for determining nine prostaglandins in the AA metabolic pathway with UHPLC-QQQ-MS/MS embodied the advantages of requiring a low amount of sample, a simple pretreatment process, and the rapid and efficient simultaneous quantification of multiple inflammatory factors. It provided a novel assay method for the pharmacological study of the AA metabolic pathway.
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