ArticleFrontiers in veterinary science2025
Loci associated with spontaneous abortion in primiparous Holstein cattle.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genome-wide association analysis reveals genetic architecture of fertility traits in Sahiwal heifers and cows.Tropical animal health and production · 2026Article
- Identifying the Genetic Basis of Fetal Loss in Cows and Heifers Through a Genome-Wide Association Analysis.Animals : an open access journal from MDPI · 2026Article
- Disentangling mature cow weight and body condition score: a comparative single-step GWAS of phenotypic pre-adjustment vs. recursive modeling.Journal of animal science · 2026Article
- Whole-genome sequencing reveals genomic diversity and selection signatures for adaptation in South African Afrikaner and Bonsmara cattle.Frontiers in genetics · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Spontaneous abortion (SA) in cattle refers to pregnancy loss occurring between days 42 and 260 of gestation. SA is costly, inefficient, and often leads to premature culling of cows. Methods: This study aimed to identify loci associated with SA in primiparous Holstein cows by conducting a genome-wide association analysis of cows bred via artificial insemination (AI; 679 controls and 69 cases that aborted) or that were embryo transfer (ET) recipients (236 controls and 41 cases) from a single dairy. Results: In AI-bred cows, 86 loci (413 single nucleotide polymorphisms or SNPs) and 168 positional candidate genes were associated (FDR <0.05) with SA, while in ET recipients, 4 loci (10 SNPs) and 16 positional candidate genes were associated (FDR <0.05) with SA. No SA-associated loci were shared between AI-bred or ET recipient cows, but nine associated loci (FDR <0.05) in AI-bred cows were shared with AI-bred heifers. Discussion: The difference in loci associated with AI-bred and ET recipient cattle may be due to differences in mechanisms associated with the maintenance of pregnancy between
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