ArticleFrontiers in neurology2025
The clinical efficacy and mechanism of gamma frequency electroacupuncture stimulation on the rehabilitation of upper limb motor function in stroke patients: study protocol of a randomized clinical trial.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The field of neuroscience has discovered that gamma oscillations (30-100 Hz) in the brain play a key role in neuroplasticity, information conduction and neuroprotective mechanisms. Electroacupuncture stimulation (ES) is a modern treatment method that combines the advantages of Chinese acupuncture with those of electrical stimulation, and is widely used in the field of stroke rehabilitation. At present, there is a lack of research on the clinical efficacy and mechanism of applying gamma frequency (40-Hz) ES, a new neuromodulation mode of integrated Chinese and Western medicine, to induce gamma oscillations and promote the rehabilitation of upper limb motor function in stroke patients. Methods and analysis: This trial uses a randomized, double-blind and controlled method to evaluate the effect of 40-Hz ES of LI11 (Quchi) acupoint on upper limb motor functional rehabilitation in stroke patients. Based on this new rehabilitation program combining Traditional Chinese medicine with modern technique, all patients will receive baseline assessment, 1-week post-intervention assessment and 2-week post-intervention assessment. The primary outcomes are the Fugl-Meyer Assessment Upper Extremity Scale. The secondary indicators include electroencephalogram, National Institutes of Health Stroke Scale, Mini-mental State Examination and Modified Barthel Index. Discussion: This trial offers novel perspectives on the application of 40-Hz electroacupuncture stimulation in neural oscillation regulation and the effectiveness of this clinically widespread technique in treating upper extremity dysfunction after a stroke and improving patients' quality of life. The results of this study will contribute to the scientific community's understanding of the potential mechanisms of this novel neuromodulation method, including changes in neural network connectivity, and improve existing clinical treatments to benefit more stroke patients. Clinical trial registration: https://www.chictr.org.cn/showprojEN.html?proj=217786, identifier ChiCTR2400082208.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.