ArticleCureus2025
Opioid Overdose Reversal With Nalmefene Nasal Spray: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the recent FDA approval of intranasal (IN) nalmefene, there is a lack of published evidence regarding its utilization, namely regarding concerns about its potential for precipitate withdrawal. In this case report, two physician investigators independently reviewed Oakland County (Michigan) Sheriff's Office (OCSO) bodycam footage, OSCO dispatch report, and the Alliance of Coalitions for Healthy Communities interview data conducted 72 hours post-overdose of a patient who received IN nalmefene following an opioid overdose, to describe clinical signs and symptoms before, during, and after administration. An increase in oxygen saturation up to 98% occurred within approximately 2.5 minutes after the initial dose. The patient also showed a marked improvement in mental status. The patient exhibited no evidence of precipitated withdrawal. This case study provides data to support that IN nalmefene can produce a rapid and effective reversal of opioid overdose. Additional studies will be important in establishing the role of IN nalmefene in the treatment of opioid overdose by first responders as well as its impact on clinical outcomes once patients arrive at the accepting medical facility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.