ArticleAmerican journal of cancer research2025
The complex interplay of TROP2 and PD-L1 in immune regulation and drug resistance in lung cancer.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Antibody drug conjugates in gynaecological cancers: navigating between opportunities and challenges.EClinicalMedicine · 2026Review
- ADC Target Profiling in NSCLC: Generalizable AI Separates TROP-2 and cMET Phenotypes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex interplay of TROP2 and PD-L1 in lung adenocarcinoma (LUAD) influences drug resistance and immunotherapy efficacy remains incompletely understood yet. In this study, we investigated the relationship between TACSTD2 (encoding TROP2) and PD-L1 expression through transcriptome analysis, immunohistochemistry, and single-cell RNA sequencing in lung cancer cell lines, tumor tissues, and immune cells, focusing on PC9 parental and drug-resistant variants. TACSTD2 expression strongly correlated with poor clinical outcomes, particularly in immunotherapy-treated patients (HR 1.71 for OS, 2.95 for PFS). Our transcriptome analysis revealed distinct resistance mechanisms involving MAPK signaling and immune receptor regulation pathways. Immunohistochemistry demonstrated significantly elevated TROP2 expression in tumor tissues compared to normal samples, with notably higher levels in PD-L1 positive specimens. We observed significant negative correlations between TACSTD2 expression and CD8
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.