ArticleAmerican journal of cancer research2025
A long-lasting PI3Kδ inhibitor zandelisib forms a water-shielded hydrogen bond with p110δ and demonstrates sustained inhibitory effects.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Targeting PI3Kδ for lymphoma and immune diseases treatment: a review.Molecular diversity · 2026Review
- Large-scale comparative virtual screening identifies novel molecular targets underlying the multi-target activity of quercetin in psoriasis.Inflammopharmacology · 2026Article
- SOX5 Orchestrates Malignant Evolution via Promoter-Centric Chromatin Remodeling in MYC-Driven B-Cell Lymphoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
12 authors.
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Abstract
Phosphatidylinositol 3-kinase isoform δ (PI3Kδ) phosphorylates phosphatidylinositol lipids, activating the AKT signaling pathway, which is crucial for essential cellular functions in B cells. Zandelisib, a selective PI3Kδ inhibitor, is under clinical development for treating B cell malignancies. Its intermittent dosing regimen sustains therapeutic effects while minimizing adverse effects. We explored zandelisib's pharmacological activity, focusing on its long-lasting property as a PI3Kδ inhibitor. To gain mechanistic insights, we compared the crystal structure of PI3Kδ in complex with zandelisib with other PI3K inhibitors. The binding kinetics of zandelisib, parsaclisib, idelalisib, and duvelisib to PI3Kδ were evaluated using surface plasmon resonance (SPR) analysis with the Biacore
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Registered trials
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