Evidence map›Paper›PMID 40521203›Full record

ArticleTheranostics2025

Association of integrated biomarkers and progression-free survival prediction in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy.

Felix L Herr, Christian Dascalescu, Ricarda Ebner, Moritz L Schnitzer, Matthias P Fabritius, Christine Schmid-Tannwald, Mathias J Zacherl, Vera Wenter, Lena M Unterrainer, Matthias Brendel and 10 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Krenning score enhances integrated biomarker models for survival prediction in PRRT-treated GEP-NET: a retrospective cohort study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Felix L HerrDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Christian DascalescuDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Ricarda EbnerDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Moritz L SchnitzerDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Matthias P FabritiusDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Christine Schmid-TannwaldDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Mathias J ZacherlDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Vera WenterDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Lena M UnterrainerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Christoph J AuernhammerInterdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM, ENETS certified Center of Excellence), LMU University Hospital, LMU Munich, Munich, Germany.
Christine SpitzwegInterdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM, ENETS certified Center of Excellence), LMU University Hospital, LMU Munich, Munich, Germany.
Thomas KnöselDepartment of Pathology, LMU University Hospital, LMU Munich, Munich, Germany.
Tanja BurkardDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Jens RickeDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Maurice M HeimerDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Gabriel T SheikhDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Clemens C CyranDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrated biomarkers that predict survival in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) receiving peptide receptor radionuclide therapy (PRRT) are still limited. This study aims to identify predictors of progression-free survival (PFS) in patients with GEP-NET undergoing two cycles of PRRT.

Indexed as

Biomarkers, TumorIntestinal NeoplasmsNeuroendocrine TumorsOctreotideOrganometallic CompoundsPancreatic NeoplasmsStomach NeoplasmsAdultAgedAged, 80 and overFemaleHumansKi-67 AntigenLutetiumMaleMiddle AgedBiomarkers, TumorKi-67 AntigenLutetiumlutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticalsReceptors, SomatostatinGEP-NEThistopathologyKi-67Krenning scoreproliferation indexPRRTsomatostatin receptor

Identifiers

PMID40521203
PMCPMC12160013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.