Evidence mapPaperPMID 40521305Full record

ArticleObesity pillars2025

Short-term pre-meal whey protein microgel supplementation reduces postprandial glycemia and appetite in adults with overweight: An open-label randomised controlled trial.

Ian J Neeland, Kostas Tsintzas, Bo Ahrén, Robert J Chilton, Ambra Giorgetti, Alric Mondragon, Rachel Ambiaux, Eugenia Migliavacca, David Philippe, Olivier Aprikian and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Obesity pillars, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06593769 (Glycemic and Appetite Effects of a Pre-meal Whey-Protein Microgel), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06593769 nacompletednot on this map

Glycemic and Appetite Effects of a Pre-meal Whey-Protein Microgel (the GAP Study)

TypeinterventionalSponsorSociété des Produits Nestlé (SPN)Ran2024 to 2024Enrolled18ConditionsGlucose Metabolism, Appetite RegulationArmswhey-protein microgel, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ian J NeelandHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, and Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Kostas TsintzasMRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Bo AhrénDepartment of Clinical Sciences, Lund University, 221 00, Lund, Sweden.
Robert J ChiltonUniversity of Texas Health Science Center, San Antonio, TX, USA.
Ambra GiorgettiSociete de Produits Nestlé, 1000, Lausanne, Switzerland.
Alric MondragonSociete de Produits Nestlé, 1000, Lausanne, Switzerland.
Rachel AmbiauxSociete de Produits Nestlé, 1000, Lausanne, Switzerland.
Eugenia MigliavaccaSociete de Produits Nestlé, 1000, Lausanne, Switzerland.
David PhilippeNestlé Health Science, 1000, Lausanne, Switzerland.
Olivier AprikianNestlé Health Science, Bridgewater, NJ, 08807, USA.
Odd Erik JohansenNestlé Health Science, 1000, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Premeal whey protein (WP) consumption may reduce postprandial glucose (PPG) levels and appetite. We assessed the effects of twice daily consumption of a low-dose non-gelling novel WP formulation (WP microgel [WPM]) on PPG, self-reported appetite, and ad-libitum food consumption. Methods: This was a randomized, prospective, open-label, controlled, single-center crossover study, and adults with BMI 27-35 kg/m Result: 18 individuals (8 females, median age 57 years, BMI 29.8 kg/m Conclusions: A 125 mL pre-meal dose of WPM consumed twice daily before breakfast and lunch for 4 days in adults with obesity significantly reduced breakfast PPG and had a moderate appetite-suppressing effect, which led to a significantly lower energy consumption during ad-libitum lunch (NCT06593769).

Identifiers

PMID40521305
PMCPMC12166780

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.