Unraveling Structural and Anticancer Properties of Pyridine-Oxadiazole Derivatives: Single-Crystal XRD, Hirshfeld Analysis, and Cytotoxicity against A549 Cells.

Yogeesha N Nayak, Deepika Dwarakanath, Keerthana Suresh Kizhakkanoodan, Rajeev K Sinha, K Sreedhara Ranganath Pai, Bharath Raja Guru, Santosh L Gaonkar

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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7 authors.

Yogeesha N NayakDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0002-3226-1905

Deepika DwarakanathDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.

Keerthana Suresh KizhakkanoodanDepartment of Biotechnology, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.

Rajeev K SinhaDepartment of Physics, Birla Institute of Technology Mesra, Ranchi 835215, India.

K Sreedhara Ranganath PaiDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.

Bharath Raja GuruDepartment of Biotechnology, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0003-2542-7740

Santosh L GaonkarDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.ORCID https://orcid.org/0000-0003-2687-6927

Funding

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6 · The paper itself

Abstract

A new series of pyridine-based 1,3,4-oxadiazole derivatives was synthesized and structurally characterized using FTIR, NMR, HRMS, and single-crystal X-ray diffraction. Hirshfeld surface analysis of the meta-methyl-substituted derivative revealed key intermolecular interactions. Cytotoxicity was evaluated against A549 lung cancer cells via MTT assay, where compound

Identifiers

PMID40521477

DOI10.1021/acsomega.5c02152

PMCPMC12163846

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.