Evidence map›Paper›PMID 40521621›Full record

Trial reportJournal of medical imaging and radiation oncology2025

SPAN-C: Results of a Phase II Clinical Trial of Stereotactic Body Radiotherapy in Pancreatic Ductal Adenocarcinoma.

Joseph Chan, Andrew Kneebone, Gabrielle Metz, Jeremy Booth, Meegan Shepherd, Carol Kwong, Chris Brown, Ian Norton, Stephen Clarke, Connie Diakos and 4 more

Registry-linked trialAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of medical imaging and radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03505229 (Stereotactic Body Radiotherapy [SBRT] for High Risk Localised Pancreatic Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03505229 naactive not recruitingnot on this map

Stereotactic Body Radiotherapy [SBRT] for High Risk Localised Pancreatic Cancer: a Phase II Study of the Department of Radiation Oncology Royal North Shore Hospital (Span-C - SBRT for Pancreatic Cancer)

TypeinterventionalSponsorRoyal North Shore HospitalRan2018 to 2028Enrolled30ConditionsHigh Risk Localised Pancreatic CancerArmsStereotactic Body Radiotherapy (SBRT)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Joseph ChanDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-2537-9729
Andrew KneeboneDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7629-504X
Gabrielle MetzDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4459-5697
Jeremy BoothDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Meegan ShepherdDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8041-8017
Carol KwongDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Chris BrownNHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.
Ian NortonNorthern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Stephen ClarkeDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Connie DiakosDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Nick PavlakisDepartment of Medical Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Anubhav MittalNorthern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Jaswinder SamraNorthern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
George HrubyDepartment of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-4193-9682

Funding

Varian Medical Systems
6 · The paper itself

Abstract

introductionThe role of stereotactic body radiotherapy (SBRT) remains unclear in the setting of pancreatic ductal adenocarcinoma (PDAC). This study aims to investigate the safety, feasibility and benefits of SBRT for PDAC in a clinical trial setting.

methodsSPAN-C was a single centre, single-arm, phase II clinical trial. Patients with locally advanced, borderline resectable, and metastatic PDAC suitable for high dose radiation were enrolled. Fiducial marker placement was mandated. Following induction chemotherapy, patients were treated with 40-45Gy in 5 fractions of external beam radiotherapy. Freedom from local failure at 12 months was the primary endpoint. Secondary endpoints included disease recurrence endpoints, acute and late toxicity, surgical outcomes, and palliative endpoints.

resultsThirty patients were enrolled. Median follow up of alive patients was 5 years (min 31 months). Twenty-six completed treatment as per protocol. Nine patients (34.6%) underwent a resection, 5 of whom had a R0 resection and 2 had a complete pathologic response. The 12-month freedom from local failure was 100% for the resected subgroup and 76.5% for the unresected subgroup. Seven patients (26.9%) had local recurrences, with 5 of these in the unresected group (29.4%). Median OS was 37.9 months for the resected subgroup and 10.7 months for the unresected subgroup. Three patients had grade 3 acute toxicity, and no patients had late high-grade toxicity.

conclusionsSBRT was safe and feasible with high rates of local control at 12 months and low rates of toxicity. It appears a valid alternative to chemo-irradiation in both the pre-operative and inoperable setting.

trial registrationClinicalTrials.gov identifier: NCT03505229.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsRadiosurgeryAdultAgedAged, 80 and overFeasibility StudiesFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalTreatment Outcomeadenocarcinomaductalpancreaticradiotherapystereotactic

Identifiers

PMID40521621
PMCPMC12317359

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.