Evidence map›Paper›PMID 40521749›Full record

Trial reportDiabetes, obesity & metabolism2025

Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low-energy diet.

Giovanni Fanni, Fleur Hukema, Susanne Hetty, Argyri Mathioudaki, Magnus Sundbom, Ulf Risérus, Joel Kullberg, Maria J Pereira, Håkan Ahlström, Jan W Eriksson

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni FanniDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-7920-8909
Fleur HukemaDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.
Susanne HettyDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.
Argyri MathioudakiDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.
Magnus SundbomDepartment of Surgical Sciences, Surgery, Uppsala University, Uppsala, Sweden.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Joel KullbergDepartment of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Maria J PereiraDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.
Håkan AhlströmDepartment of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Jan W ErikssonDepartment of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-2639-9481

Funding

Agnes och Mac Rudbergs StiftelseAkademiska SjukhusetAstraZenecaDiabetesförbundetExcellence of Diabetes Research in Sweden (EXODIAB)Hjärt-Lungfonden 20220129Hjärt-Lungfonden 20240402HORIZON EUROPE European Innovation Council 101080329HORIZON EUROPE Marie Sklodowska-Curie Actions H2020-MSCA-ITN-721236Novo Nordisk Fonden NNF20OC0063864Novo Nordisk Fonden NNF23OC0084483P. O. Zetterlings stiftelseStiftelsen Familjen Ernfors FondVetenskapsrådet 2024-03344
6 · The paper itself

Abstract

aimsIn addition to weight loss, obesity surgery (OS) leads to metabolic improvements that seem at least partly independent of weight loss and are also mediated by various endocrine pathways and the brain. For the first time, we compared the short-term effects of weight loss achieved by either OS or a low-energy diet (LED) on several hormonal systems, at fasting and upon an oral glucose challenge. MATERIALS AND

methodsThis study presents sub-analyses from a randomized controlled trial including 24 participants with obesity but without diabetes (BMI 35-45 kg/m

resultsAt 4 weeks, similar weight loss was achieved for the two interventions (7.7 for OS vs. 7.4% for LED). glucagon-like peptide-1 and peptide YY secretion during the OGTT increased after OS (p < 0.001 for OGTT

conclusionRapid and extensive hormonal changes occur after OS, but not LED, despite similar weight loss. Of note, few differences were seen in the fasting state, whereas multiple endocrine pathways were affected during the oral glucose challenge. The findings suggest altered responses to oral glucose after OS in several hypothalamus-pituitary endocrine axes and peripheral endocrine glands.

Indexed as

Bariatric SurgeryCaloric RestrictionObesityWeight LossAdaptation, PhysiologicalAdultBlood GlucoseDiet, ReducingFastingFemaleGlucagonGlucagon-Like Peptide 1Glucose Tolerance TestHumansHydrocortisoneInsulin-Like Growth Factor IBlood GlucoseGlucagonGlucagon-Like Peptide 1HydrocortisoneInsulin-Like Growth Factor IPeptide YYSex Hormone-Binding Globulingastric bypasslow‐energy dietobesity surgeryOGTTpituitary hormones

Identifiers

PMID40521749
PMCPMC12326915

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.