SynthesisMaternal & child nutrition2025
Early Long-Chain Polyunsaturated Fatty Acids Supplementation on Long- and Short-Term Neurodevelopmental Outcomes in Preterm or Low Birth Weight Infants: A Meta-Analysis.
Synthesis in Maternal & child nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Omega-3 Fatty Acid Docosahexaenoic Acid Supplementation in Individuals During Pregnancy on Neurodevelopment and Growth of Offspring: Systematic Review and Meta-Analysis.Developmental psychobiology · 2026Pooled it
- Cross-sectional description of early postnatal fatty acid patterns in delivered preterm infants.iScience · 2026Article
- DHA: Nutritional Programming During the First 1000 Days of Life.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-chain polyunsaturated fatty acid (LCPUFA) supplementation on neurodevelopmental outcomes in preterm or low birth weight (LBW) infants is controversial. This study aims to evaluate the effects of early LCPUFA supplementation on short- and long-term neurodevelopmental outcomes in preterm or LBW infants. This study was previously registered (CRD42024503566). We searched MEDLINE, Embase, PsycInfo, ClinicalTrials.gov and Cochrane Database through January 2024. Randomised clinical trials (RCTs) or follow-up studies comparing early LCPUFA supplementation to placebo or no supplementation in preterm or LBW infants were included. Outcomes assessed included long-term (≥ 5 years) and short-term (< 5 years) measures, such as IQ, neurodevelopmental impairment (NDI), mental development index (MDI) and psychomotor development index (PDI). A random-effects model was used to pool outcome data. Thirteen RCTs involving 3360 participants were analysed. Due to imprecision, it was unclear whether LCPUFA supplementation had a beneficial or harmful effect on long-term IQ (SMD, 0.00; 95% CI, -0.32 to 0.33; I2 = 63%; very low certainty) or on the risk of NDI (RR, 0.77; 95% CI, 0.55-1.08; low certainty), as the confidence intervals allow for potentially clinically meaningful effects. LCPUFA supplementation may reduce the risk of intellectual disability (RR, 0.58; 95% CI, 0.36-0.93; moderate certainty). The evidence did not clearly show short-term neurodevelopmental benefits. Evidence quality varied from moderate to very low. LCPUFA supplementation may not improve most neurodevelopmental outcomes, but could reduce the risk of intellectual disability in preterm or LBW infants. Further studies with long-term follow-up are recommended.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.