Evidence map›Paper›PMID 40521965›Full record

ArticleJournal of materials chemistry. B2025

Towards the development of supramolecular self-associating amphiphiles as antibiofilm agents against

Kira L F Hilton, Hendrik J F Steyn, Kusasalethu S Luthuli, Matthew Rice, Bree R Streather, Esther Sweeney, Lisa J White, Findley R Morgan, Jennifer Rankin, Jennifer Baker and 9 more

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kira L F HiltonSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.ORCID http://orcid.org/0000-0001-6425-0947
Hendrik J F SteynDepartment of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Free State, South Africa, 9301. PohlCH@ufs.ac.za.
Kusasalethu S LuthuliDepartment of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Free State, South Africa, 9301. PohlCH@ufs.ac.za.
Matthew RiceSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.
Bree R StreatherSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.
Esther SweeneyUKHSA, Science Group, Manor Farm Road, Salisbury, SP4 0JG, UK. Charlotte.Hind@UKHSA.gov.uk.ORCID http://orcid.org/0000-0003-2653-0934
Lisa J WhiteSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.ORCID http://orcid.org/0000-0001-9492-6143
Findley R MorganSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.
Jennifer RankinCancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Jennifer BakerCancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK.ORCID http://orcid.org/0009-0008-1290-7845
Charlotte BennettCancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Hollie B WilsonCancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Perry A HaileySchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.
Michelle D GarrettSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.ORCID http://orcid.org/0000-0002-3939-1673
Jose L Ortega-RoldanSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.ORCID http://orcid.org/0000-0002-6316-4390
J Mark SuttonUKHSA, Science Group, Manor Farm Road, Salisbury, SP4 0JG, UK. Charlotte.Hind@UKHSA.gov.uk.
Charlotte K HindUKHSA, Science Group, Manor Farm Road, Salisbury, SP4 0JG, UK. Charlotte.Hind@UKHSA.gov.uk.ORCID http://orcid.org/0000-0002-3763-3106
Carolina H PohlDepartment of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Free State, South Africa, 9301. PohlCH@ufs.ac.za.ORCID http://orcid.org/0000-0001-6928-5663
Jennifer R HiscockSchool of Natural Sciences, University of Kent, Canterbury, UK, CT2 7NH. J.R.Hiscock@Kent.ac.uk.ORCID http://orcid.org/0000-0002-1406-8802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of antimicrobial resistant (AMR) infection represents a growing threat to the global population and to economic health. The majority of antimicrobial innovations are developed against planktonic microorganisms, however those same microorganisms contained within a biofilm can become over 1000 times more resistant to antimicrobial (including antibiotic) agents. Supramolecular self-associating amphiphiles (SSAs) are a class of amphiphilic salts and related compounds that have shown the potential for development into antibiofilm agents. Within the scope of this work we present five structurally diverse SSAs. We characterise the self-associative properties of these SSAs in the solid state and in solution, before analysing the interactions of these agents with model synthetic membranes and determining their antibiofilm activity against WHO high/critical priority pathogens,

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBiofilmsCandida albicansPseudomonas aeruginosaSurface-Active AgentsMacromolecular SubstancesMicrobial Sensitivity TestsMolecular StructureAnti-Bacterial AgentsAntifungal AgentsMacromolecular SubstancesSurface-Active Agents

Identifiers

PMID40521965
PMCPMC12169104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.