Evidence map›Paper›PMID 40522106›Full record

ArticleMicrobiology spectrum2025

Comparison of virulence and resistance genes in

Adriana Garzon, Craig Miramontes, Bart C Weimer, Rodrigo Profeta, Alejandro Hoyos-Jaramillo, Heather M Fritz, Richard V Pereira

Abstract readComparative Study
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Study on the Pathogenic Mechanism ofPathogens (Basel, Switzerland) · 2026
    Review
  3. Exploring clonality ofMicrobiology spectrum · 2026
    Article
  4. Genomic diversity and virulence ofMicrobial genomics · 2026
    Article
  5. Article
  6. Genomic diversity and host-specificity inFrontiers in microbiology · 2026
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adriana GarzonDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0003-3464-6670
Craig MiramontesDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0009-0003-6079-7576
Bart C WeimerDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0002-7471-1978
Rodrigo ProfetaDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.
Alejandro Hoyos-JaramilloDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.
Heather M FritzCalifornia Animal Health and Food Safety Lab, University of California, Davis, California, USA.
Richard V PereiraDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID 0000-0003-2028-8761

Funding

U.S. Department of Agriculture CA-V-PHR-4142-H
6 · The paper itself

Abstract

IMPORTANCE: This case-control study provides key microbial ecological advances by elucidating the role of bacteria in the bovine respiratory disease complex in dairy cattle. Previous research has identified specific virulence factors in both bacterial genomes that resulted in disease. Our results challenge this perception and are of high impact, revealing that the pan-genome of both bacteria did not differentiate among the clinical cases or age groups, and a specific pathogenic pathotype was not evident in the isolates from this study, and it did not emerge when including additional public whole-genome sequences to increase the analytical power of the analysis (the first study to use this approach to evaluate bovine respiratory disease in cattle). In addition to these novel discoveries, this study describes the first population-scale genomic comparison of both

Indexed as

Bovine Respiratory Disease ComplexCattle DiseasesDrug Resistance, BacterialMannheimia haemolyticaPasteurella InfectionsPasteurella multocidaVirulence FactorsAnimalsAnti-Bacterial AgentsCase-Control StudiesCattleFemaleGenome, BacterialVirulenceWhole Genome SequencingAnti-Bacterial AgentsVirulence Factorsantimicrobial resistanceBRDdairy cattleWGSwhole-genome sequencing

Identifiers

PMID40522106
PMCPMC12323314

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.