ArticleLangenbeck's archives of surgery2025
Individual multimodal prehabilitation in high-risk patients undergoing major abdominal surgery following neoadjuvant treatment - a feasibility study.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Nutritional prehabilitation strategies in abdominal surgery.Current opinion in clinical nutrition and metabolic care · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite advancements in medicine, perioperative complications and functional decline remain challenges for patients undergoing major abdominal surgery, particularly in high-risk individuals with limited functional capacity and impaired nutritional status. Prehabilitation, which involves interventions before surgery, shows promise in addressing these issues, but the heterogeneity of studies limits specific recommendations. The integration of prehabilitation into clinical practice with special regard to the setting and modalities of treatment also remain unclear.
methodsAs a feasibility study for home-based prehabilitation high-risk patients (age ≥ 70 years, ASA ≥ 3) undergoing neoadjuvant treatment for non-metastatic esophageal, gastric, or rectal cancer, followed by oncological resection were included. A six-week multimodal supervised home-based prehabilitation program, including nutritional therapy, exercise, and psychological support, was implemented after neoadjuvant treatment and before surgery. Functional, nutritional, and quality of life (QoL) assessments were conducted at multiple points. Feasibility and adherence were assessed. Secondary explorative outcome measures included complication rates, hospital stay, readmission, and mortality, which were compared to a matched cohort.
resultsOf 24 enrolled patients, 20 completed the program, with high adherence to home-based workouts (91.8%), respiratory exercises (92.9%), and oral nutritional supplements (ONS) (88.7%). Functional and nutritional improvements were observed, including improved sit-to-stand performance (p = 0.025) and serum albumin levels (p = 0.001). QoL improved in the physical function domain (p = 0.009). Postoperative outcomes were similar between groups.
conclusionA supervised home-based prehabilitation program is feasible for high-risk patients, with high adherence to interventions and potential benefits in functional and nutritional status. Further research is needed to optimize program content, identify optimal patient populations, and assess long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.