Evidence map›Paper›PMID 40522665›Full record

ReviewExpert opinion on drug metabolism & toxicology2025

Evaluating the drug interactions in kratom usage: clinical application.

Leena R Dhoble, Abhishek Gour, Christopher R McCurdy, Abhisheak Sharma

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug metabolism & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Leena R DhobleDepartment of Pharmaceutics, University of Florida, Gainesville, FL, USA.
Abhishek GourDepartment of Pharmaceutics, University of Florida, Gainesville, FL, USA.
Christopher R McCurdyDepartment of Pharmaceutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8695-2915
Abhisheak SharmaDepartment of Pharmaceutics, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-0553-4039

Funding

Opioid use disorders: UF Pharmacy medications discovery and developmentUH3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI Christopher R McCurdy, Lance R. McMahon · 2022 to 2023
$3.7M
NIDA NIH HHS R01 DA047855NIDA NIH HHS R21 DA055908NIDA NIH HHS UH3 DA048353
6 · The paper itself

Abstract

introductionAREAS COVERED: Google Scholar and PubMed, along with FAERS database, were systematically searched to evaluate the clinical applications of kratom by examining its drug interactions, which can significantly impact the pharmacokinetics and pharmacodynamics of concomitant medications. By examining current evidence, this review aims to highlight the importance of establishing safe clinical practices and protocols for healthcare providers and patients. EXPERT OPINION: Evaluating drug interactions in kratom usage is clinically imperative because kratom's bioactive alkaloids can interact with the pharmacokinetic and pharmacodynamic processes of concurrent medications, potentially resulting in adverse effects or compromised therapeutic outcomes. This review presents an expert opinion on the clinical relevance of kratom's interactions with drugs, aiming to inform clinical practice, highlight ethical and regulatory considerations, and propose future research directions to improve the understanding of kratom's pharmacological profile and enhance user safety.

Indexed as

Herb-Drug InteractionsMitragynaPlant ExtractsAnimalsAnti-Anxiety AgentsDose-Response Relationship, DrugDrug InteractionsHumansOpioid-Related DisordersAnti-Anxiety AgentsPlant Extractsdrug interactionsKratomMitragyna speciosamitragyninepharmacodynamicspharmacokinetics

Identifiers

PMID40522665
PMCPMC12278816

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.