Evidence map›Paper›PMID 40522857›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025

Lifetime trauma exposure and accelerated epigenetic aging among midlife women.

Rebecca C Thurston, Caroline Y Doyle, Cynthia D J Kusters, Yuefang Chang, Karestan Koenen, Pauline Maki, Judith E Carroll

Abstract read
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In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca C ThurstonDepartment of Psychiatry, University of Pittsburgh.ORCID 0000-0001-6580-1202
Caroline Y DoyleDepartment of Psychiatry, University of Pittsburgh.
Cynthia D J KustersCousins Center for Psychoneuroimmunology, University of California, Los Angeles.ORCID 0000-0001-8099-9026
Yuefang ChangDepartment of Neurosurgery, University of Pittsburgh.
Karestan KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health.
Pauline MakiDepartment of Psychiatry, University of Illinois at Chicago.
Judith E CarrollJane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
Menopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1M
Menopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8M
Interdisciplinary Mentoring and Research in Womens Cardiovascular HealthK24HL123565 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2014 to 2023
$1.0M
Biological pathways linking sleep health to Alzheimers disease and cognitive declineK01AG081542 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Cynthia Diana Johanna Kusters · 2024 to 2026
$388k
National Institutes of Health; National Heart, Lung, and Blood InstituteNational Institutes of Health; National Institute on AgingNCATS NIH HHS UL1 TR000005NHLBI NIH HHS K24 HL123565NHLBI NIH HHS T32 HL007560NIA NIH HHS K01 AG081542NIA NIH HHS R01 AG053504NIA NIH HHS RF1 AG053504NIH HHS
6 · The paper itself

Abstract

objectiveTrauma exposure may be linked to accelerated biological aging. However, studies have largely considered childhood abuse, with limited consideration of lifetime trauma exposure, particularly for women. Furthermore, few studies have considered newer epigenetic clocks, which have enhanced links with health outcomes. Among midlife women, we investigated whether lifetime trauma exposure is associated with older epigenetic age with several generations of clocks. We explored associations between childhood maltreatment and epigenetic age and racial differences in associations between trauma and epigenetic age.

methodTwo hundred sixteen women (

resultsRelative to women without trauma exposure, those with ≥ 2 lifetime traumas had older epigenetic age, GrimAge, 1:

conclusionAmong midlife women, greater lifetime trauma and possibly childhood sexual abuse were associated with older epigenetic age, independent of chronologic age. Black women may be particularly affected. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Indexed as

Adult Survivors of Child AbuseAgingEpigenesis, GeneticPsychological TraumaBlack or African AmericanFemaleHumansMiddle AgedWhite

Identifiers

PMID40522857
PMCPMC12261588

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.