Evidence map›Paper›PMID 40522956›Full record

ArticlePloS one2025

Brain microdialysis to assess trace elements dynamics in traumatic brain injury: An exploratory study.

Adriano Bernini, Sébastien Lenglet, Mette M Berger, Samia Abed-Maillard, Roy Thomas Daniel, Mahmoud Messerer, Mauro Oddo, Jean-Daniel Chiche, Marc Augsburger, Nawfel Ben-Hamouda

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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriano BerniniDepartment of Clinical Neurosciences and NeuroDigital@NeuroTech, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Sébastien LengletUnit of Forensic Toxicology and Chemistry, University Center of Legal Medicine, Lausanne-Geneva, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Mette M BergerDepartment of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-5427-1648
Samia Abed-MaillardClinical Research Center, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Roy Thomas DanielDepartment of Clinical Neuroscience, Service of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Mahmoud MessererDepartment of Clinical Neuroscience, Service of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Mauro OddoDirectorate for Innovation and Clinical Research, Lausanne University Hospital (CHUV), and University of Lausanne, Lausanne, Switzerland.
Jean-Daniel ChicheDepartment of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Marc AugsburgerUnit of Forensic Toxicology and Chemistry, University Center of Legal Medicine, Lausanne-Geneva, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Nawfel Ben-HamoudaDepartment of Adult Intensive Care Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4428-5223

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrace elements (TEs) status alterations in the brain have been linked to neurodegenerative diseases. However, data on TEs in living humans and in the post-traumatic conditions are scarce. Some TEs (copper - Cu, selenium - Se, zinc - Zn) are involved in essential antioxidant defence. This study aims to measure the evolution of TEs concentrations in the brain and serum of severe traumatic brain injury (TBI) patients over time.

methodsTwenty adult patients with severe TBI were monitored using cerebral microdialysis (CMD) and blood sampling within three days of intensive care unit admission. TEs levels were measured using inductively coupled plasma system coupled to mass spectrometry.

resultsTEs concentrations of chromium - Cr, Cu, cobalt - Co, manganese - Mn, molybdenum - Mo, Se, and Zn were quantified in brain interstitial fluid and serum. While serum and CMD levels did not differ significantly for Co, Mo and Mn, and modest differences was observed for Cr and Zn, significant differences were observed for Cu and Se with higher serum levels (8-10-fold higher) compared to CMD. No correlation was found between serum and brain TEs levels, except for Mo.

conclusionThis study provides novel TEs concentration data in living TBI patients, the largest differences between brain and serum being observed for Cu and Se, serving as a basis for further research on TEs dynamics in acute brain injury.

Indexed as

BrainBrain Injuries, TraumaticMicrodialysisTrace ElementsAdultAgedCopperFemaleHumansMaleMiddle AgedSeleniumYoung AdultZincCopperSeleniumTrace ElementsZinc

Identifiers

PMID40522956
PMCPMC12169518

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.