ArticleEnvironmental science & technology2025
An Online Measurement Approach to Monitor the Deposition of Diesel Exhaust Particles on Lung Cells In Vitro.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
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Abstract
Diesel exhaust particles (DEPs) can deposit onto the respiratory epithelial surface upon inhalation. The quantification of DEP deposition on cells is important for understanding dose-response relationships within tissues. However, continuous, nondestructive methods for monitoring DEP deposition on cells remain challenging. We investigated a miniaturized thermosensitive detection system (CalorQuanti) and integrated it into the VITROCELL Cloud Alpha system, the so-called Cloud Alpha/CalorQuanti, to combine cell exposure to particles at the air-liquid interface (ALI) and online particle monitoring on cells. The Cloud Alpha/CalorQuanti demonstrates uniform particle deposition, providing the basis for online monitoring of particles on cells. With low detection limits (93 to 415 ng/cm
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