Evidence map›Paper›PMID 40523800›Full record

ArticleLife science alliance2025

No evidence that human GIGYF2 interacts with GRB10: implications for human disease.

Jung-Hyun Choi, Israel Shpilman, Niaz Mahmood, Shaghayegh Farhangmehr, Ulrich Braunschweig, Nathalia Gomide Cruz, Jun Luo, Reese Jalal Ladak, Angelos Pistofidis, Jiannis Ragoussis and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jung-Hyun ChoiRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada.
Israel ShpilmanRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada.ORCID 0009-0007-7113-5673
Niaz MahmoodRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada niaz.mahmood@mcgill.ca.ORCID 0000-0003-4018-5516
Shaghayegh FarhangmehrDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Ulrich BraunschweigDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.ORCID 0000-0001-6653-0926
Nathalia Gomide CruzMcGill Genome Centre, Victor Philip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Canada.
Jun LuoRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada.
Reese Jalal LadakRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada.
Angelos PistofidisDepartment of Biochemistry, McGill University, Montreal, Canada.
Jiannis RagoussisMcGill Genome Centre, Victor Philip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Canada.
T Martin SchmeingDepartment of Biochemistry, McGill University, Montreal, Canada.
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.ORCID 0000-0002-5129-7081
Benjamin J BlencoweDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Nahum SonenbergRosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Canada nahum.sonenberg@mcgill.ca.ORCID 0000-0002-4707-8759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GIGYF2 (growth factor receptor-bound protein 10 [GRB10]-interacting GYF [glycine-tyrosine-phenylalanine] protein 2) reduces mRNA stability and translation via microRNAs, ribosome quality control, and several RNA-binding proteins. GIGYF2 was first identified in mouse cell lines as an interacting partner with GRB10, which binds to the insulin receptor and the insulin-like growth factor receptor 1. Mutations in the human

Indexed as

Carrier ProteinsGRB10 Adaptor ProteinAnimalsCell LineHEK293 CellsHumansMiceMutationProtein BindingSignal TransductionCarrier ProteinsGIGYF2 protein, humanGRB10 Adaptor ProteinGRB10 protein, human

Identifiers

PMID40523800
PMCPMC12171015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.