ArticleNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2025
Biological sex and age-associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross-sectional study.
Article in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.Cureus · 2026Review
- CT-Derived Pectoralis Muscle Measurements and All-Cause Mortality in COPD.Diagnostics (Basel, Switzerland) · 2026Article
- Spirometric Lung Function Patterns Across Body Mass Index Categories in Ghana: A Tertiary Care Perspective.Pulmonary medicine · 2026Article
- Diagnostic value of geriatric nutritional risk index and phase angle for malnutrition in patients with COPD: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Beyond inhaled medications: precision medicine and biologic therapies targeting the IL-33/TSLP/type 2 axis in COPD.Frontiers in immunology · 2026Review
- Biological sex and age-associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundBiological sex plays a role in systemic features of patients with Chronic Obstructive Pulmonary Disease (COPD). We investigated whether male and female COPD patients show distinct trajectories in muscle and brain health decline during aging.
methodsIn total 228 patients (age >50 years) with stable COPD (GOLD: II-IV) were stratified into four groups based on their sex and age (50-70 years vs ≥70 years). Body composition (DXA), muscle strength (dynamometry), cognitive function and well-being (assessments and questionnaires), and risk factors of poor systemic health were analyzed in these groups.
resultsBody weight and lean mass remain unchanged with aging. The ≥70 years males showed higher visceral adipose tissue and lower muscle strength whereas females showed lower fat mass and fat-free mass index, and worse cognitive performance compared with their younger counterparts (P < 0.04). In males, lower physical activity was associated with higher visceral adipose tissue and lower muscle function, whereas poor cognition was associated with low O
conclusionAging in male COPD patients is characterized by metabolic syndrome features and muscle weakness whereas aging in female COPD patients is associated with weight loss, sarcopenia, and cognitive decline. The observed systemic changes were influenced by different combinations of risk factors in male and female COPD patients. Our findings indicate that sex-specific therapies need to be considered when treating older patients with COPD.
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