ArticleJournal of rehabilitation medicine2025
Differential patterns of the relationship between exercise dose and mortality risk across severities of airflow limitation: a prospective cohort study with a 5-year follow-up period.
Article in Journal of rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
objectiveThis study examines the dose-response relationship between physical activity (PA) and all-cause mortality across different severities of airflow limitation, identifying threshold effects that yield new insights into the PA-mortality association.
designA prospective cohort study with a 5-year follow-up (2018-2023), employing multivariate Cox models and penalized spline smoothing to assess non-linear associations. SUBJECTS/PATIENTS: A total of 2,975 individuals from a cohort categorized by airflow limitation severity (normal, GOLD 1-4).
methodsPA levels were quantified in metabolic equivalent hours per week (MET·h/week). Cox proportional hazards models were used to evaluate PA-mortality associations, with penalized spline analysis detecting threshold effects.
resultsIdentified thresholds were 41.50 MET·h/week (95% CI: 23.03-64.22) for normal lung function and 13.21 MET·h/week (95% CI: 9.67-16.14) for GOLD 1. Below these thresholds, higher PA levels were associated with a significant reduction in mortality risk (HR = 0.66, HR = 0.41, respectively). In GOLD 2, PA levels below the threshold were associated with a lower mortality risk (HR=0.85), whereas PA exceeding the threshold was associated with a higher mortality risk (HR = 1.23). No significant associations were observed in GOLD 3-4.
conclusionPA demonstrates a non-linear, threshold-dependent association with mortality. These findings underscore the importance of individualized PA recommendations for optimizing health outcomes in individuals with chronic respiratory conditions.
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