Evidence map›Paper›PMID 40524609›Full record

ArticleJournal of clinical periodontology2025

Glomerular Haematopoietic Prostaglandin D Synthase-Prostaglandin D2 Axis Contributes to the Periodontitis-Related Exacerbation of Diabetic Nephropathy in KK-A

Kohei Sato, Takanori Shinjo, Tatsuro Zeze, Al-Kafee Ahmed, Honoka Otsuka, Hisashi Yokomizo, Naoichi Sato, Mio Imagawa, Yuki Nishimura, Naoaki Ryo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kohei SatoSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Takanori ShinjoSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-8269-2826
Tatsuro ZezeSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Al-Kafee AhmedSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Honoka OtsukaSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Hisashi YokomizoDepartment of Endocrinology and Diabetes, Fukuoka University School of Medicine, Fukuoka, Japan.
Naoichi SatoDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Fukuoka, Japan.
Mio ImagawaSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Yuki NishimuraSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Naoaki RyoSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Akiko YamashitaSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Takao FukudaSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Terukazu SanuiSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Misaki IwashitaDepartment of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Fusanori NishimuraSection of Periodontology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Funding

8020 Promotion Foundation 20-02-13Grant-in-Aid for Research Activity Start-Up 24K23591Grant-in-Aid for Scientific Research (B) 24K02622Ichiro Kanehara Foundation, Takeda Science Foundation and Qdai-jump Research Program from Kyushu University 02230Japan Science and Technology Agency (JST) SPRING JPMJSP2136Japan Society for the Promotion of Science (JSPS) 23K09170Suzuken Memorial Foundation 23-073
6 · The paper itself

Abstract

aimsRecent clinical studies have proposed a potential association between chronic kidney diseases, including diabetic nephropathy (DN) and periodontitis. Nevertheless, the causal relationship of periodontitis with DN and the underlying molecular mechanisms remain unclear. MATERIALS AND

methodsLigature-induced experimental periodontitis (LIP) was induced in KK-A

resultsLIP aggravated renal dysfunction and glomerular pathologies in KK-A

conclusionPeriodontitis may contribute to DN progression via the glomerular HPGDS-PGD2 axis. These results suggest a novel mechanism in periodontitis-related DN progression.

Indexed as

Diabetic NephropathiesIntramolecular OxidoreductasesKidney GlomerulusLipocalinsPeriodontitisProstaglandin D2AnimalsDiabetes Mellitus, Type 2Disease Models, AnimalDisease ProgressionFemaleHumansMaleMiceIntramolecular OxidoreductasesLipocalinsProstaglandin D2prostaglandin R2 D-isomerasediabetic nephropathyglomerulihaematopoietic prostaglandin D synthaseperiodontal medicineperiodontitisprostaglandin D2

Identifiers

PMID40524609
PMCPMC12259406

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.