Evidence map›Paper›PMID 40525721›Full record

ArticleImmunity, inflammation and disease2025

Utility of Prognostic Nutritional Index and Systemic Immune-Inflammation Index Inpatients With Sudden Sensorineural Hearing Loss: A Large Prospective Cohort Study.

Xu Zhang, Junyi Wu, Wentao Zhang, Maohua Wang, Bing Guan, Qiao Jiang, Chunping Yang

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PubMed Full text at PMC Publisher
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Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xu ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0009-0009-3257-1012
Junyi WuDepartment of Otolaryngology-Head and Neck Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.ORCID 0009-0002-0700-5405
Wentao ZhangDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0001-6037-6710
Maohua WangDepartment of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Foshan, Hearing and Balance Medical Engineering Technology Center of Guangdong, Foshan, Guangdong, China.ORCID 0000-0002-5985-2430
Bing GuanDepartment of Otolaryngology-Head and Neck Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Qiao JiangDepartment of Neurology, Deyang Fifth Hospital, Deyang, Sichuan, China.
Chunping YangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0002-9725-0916

Funding

This study was funded by the National Natural Science Foundation of China (No. 82160211) and the Jiangxi Provincial Nature Science Foundation (No. 2021BAG70031).
6 · The paper itself

Abstract

backgroundThis study mainly explores the correlation between prognostic nutritional index (PNI) and systemic immune inflammatory index (SII) and sudden sensorineural hearing loss (SSNHL).

methodsIn this study, 150 SSNHL patients (average age 48.98 ± 16.45 years; 48.92% male, 50.93% female) were categorized into effective and ineffective treatment groups. Additionally, 150 healthy volunteers (average age 49.49 ± 9.75 years; 51.08% male, 49.07% female) served as the control group. Baseline characteristics, clinical data, and laboratory results were collected, and SII and PNI were calculated for analysis. Linear correlation, logistic regression, and receiver characteristic curve analyses were conducted to explore the link between immune nutrition levels and SSNHL.

resultsIn the SSNHL group, PNI was significantly lower, while SII, platelet, and neutrophil counts were notably higher compared to controls (p < 0.001). Logistic regression identified low PNI (OR = 0.878), high SII (OR = 1.005), and elevated neutrophils (OR = 1.758) as predictors of SSNHL. Data comparison showed higher nutritional levels in the effective treatment group than in the ineffective group. Logistic regression indicated that low PNI (OR = 1.075) and high SII (OR = 1.004) were strongly linked to treatment outcomes.

conclusionThere is a relationship between the body's immune nutrition level and the occurrence and development of SSNHL. Lower PNI and higher SII are associated with the occurrence of SSNHL and poor outcomes. However, further research into the underlying mechanisms is needed.

Indexed as

Hearing Loss, SensorineuralHearing Loss, SuddenInflammationNutritional StatusNutrition AssessmentAdultAgedFemaleHumansInpatientsMaleMiddle AgedNeutrophilsPrognosisProspective Studiesimmune nutritional levelprognostic nutritional indexsudden sensorineural hearing losssystemic immune inflammatory index

Identifiers

PMID40525721
PMCPMC12171996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.