ReviewACS applied bio materials2025
Plasmonic ELISA for Biomarker Detection: A Review of Mechanisms, Functionalization Strategies, and Emerging Modalities.
Review in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Sensitive detection of unopposed estrogen using estrogen receptor functionalized nanoprobes for cancer diagnosis.Discover nano · 2026Review
- Advancements and Emerging Trends in the Detection of Sweet Potato Diseases: A Comprehensive Review.ACS omega · 2026Review
- Research on the Anti-breast Hyperplasia Mechanism of Liqi Sanjie Granules Based on Network Pharmacological Analysis and Experimental Verification.Current drug targets · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmonic enzyme-linked immunosorbent assay (ELISA) effectively integrates noble metal nanostructures with traditional immunoassays, facilitating rapid, ultrasensitive, and multiplexed biomarker detection. By leveraging localized surface plasmon resonance modulations instigated by biocatalytic reactions and analyte binding, these assays achieve signal amplification through growth, etching, and aggregation mechanisms. Such methodologies significantly enhance detection limits by factors ranging from 10- to over 1000-fold, attaining sensitivity at the subpicogram per milliliter level. Robust surface functionalization methods, including electrostatic adsorption, covalent coupling, and affinity binding, ensure stable immobilization of antibodies while preserving the activity of the nanozymes. Incorporating advanced two-dimensional nanomaterials, such as graphene derivatives and MXenes, further augments the sensitivity (up to ∼200-fold), assay stability, and potential for miniaturization. Emerging modalities, including electrochemical techniques, microfluidics, photothermal methods, surface-enhanced infrared absorption (SEIRA), surface-enhanced Raman scattering, and CRISPR-enabled ELISA, extend the analytical versatility, multiplexing capabilities, and operational speed. Clinical trials, alongside real-world studies, substantiate the efficacy of plasmonic ELISA platforms in early cancer detection, diagnostic evaluation of infectious diseases, and monitoring cardiovascular biomarkers, demonstrating performance comparable to or exceeding that of traditional methodologies. Despite significant advancements, challenges persist with regard to assay standardization, multiplex integration, and large-scale manufacturing. This review presents a comprehensive overview of recent developments, identifies critical knowledge gaps, and outlines future perspectives to expedite the clinical translation of plasmonic ELISA technologies for precision medicine and global health applications.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.