Evidence map›Paper›PMID 40526039›Full record

ArticleBiomacromolecules2025

Strategic Design of Biocompatible, Glistening-Free, and Foldable Artificial Intraocular Lenses Based on Hydro-Amphiphilic Ternary Copolymers.

Cheng-Ti Hu, Zhi-Xuan Liang, Jhen-Yu Luo, Po-Hsun Chiu, Annabelle I Day, Chih-Chen Hsieh, Po-Jen Shih, Jia-Han Li, Bo-I Kuo, I-Jong Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng-Ti HuDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0009-0003-9494-815X
Zhi-Xuan LiangDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Jhen-Yu LuoInstitute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
Po-Hsun ChiuDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Annabelle I DayInstitute of Neuroscience, National Yang-Ming Chiao-Tung University, Taipei 112304, Taiwan.
Chih-Chen HsiehDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-8933-6077
Po-Jen ShihDepartment of Biomedical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Jia-Han LiDepartment of Engineering Science and Ocean Engineering, National Taiwan University, Taipei 10617, Taiwan.
Bo-I KuoDepartment of Ophthalmology, National Taiwan University Hospital, Taipei 100225, Taiwan.
I-Jong WangDepartment of Ophthalmology, National Taiwan University Hospital, Taipei 100225, Taiwan.
Jia-Yush YenDepartment of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.
Chi-An DaiDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0003-2613-3373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of cataracts underscores the urgent need for intraocular lens (IOL) materials that provide optical clarity, foldability, glistening resistance, and long-term biocompatibility. In this study, we developed hydro-amphiphilic ternary copolymers composed of styrene, hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) phenyl ether acrylate (PEGPEA) to address these requirements. This rational design integrates the strength and refractive index of hydrophobic styrene with the flexibility and hydrophilicity of HEMA and PEGPEA. The optimized formulation (H3), comprising 50 wt % HEMA, 30 wt % PEGPEA, and 20 wt % styrene, showed excellent transparency after accelerated aging, sufficient modulus and elongation for safe surgical handling, and low cytotoxicity in CCK-8 assays. Cytokine analyses revealed no significant inflammatory response compared to a commercial hydrophobic acrylic IOL. These findings highlight hydro-amphiphilic copolymers as a promising next-generation material platform for IOLs, offering a biocompatible, glistening-free, and foldable solution for enhanced surgical outcomes and long-term patient satisfaction.

Indexed as

Biocompatible MaterialsLenses, IntraocularPolyethylene GlycolsPolymersAnimalsHumansHydrophobic and Hydrophilic InteractionsMaterials TestingMethacrylatesMiceBiocompatible Materialshydroxyethyl methacrylateMethacrylatesPolyethylene GlycolsPolymers

Identifiers

PMID40526039
PMCPMC12264951

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.