Evidence map›Paper›PMID 40526204›Full record

GuidelineJournal of general internal medicine2025

Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Benefits.

Emily Brunner, Chwen-Yuen A Chen, Tracy Klein, Donovan Maust, Maryann Mazer-Amirshahi, Marcia Mecca, Deanna Najera, Chinyere Ogbonna, Kiran F Rajneesh, Elizabeth Roll and 12 more

Abstract readPractice GuidelineSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
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  9. Review
  10. Article
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  13. Article
  14. Psychotropic medication use and bone fracture risk among patients with multiple sclerosis: a real-world study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  15. Pharmacotherapy of major depressive disorder in older adults: from an evidence-informed stepwise algorithm to precision medicine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Emily BrunnerHazelden Betty Ford Foundation, Minneapolis, MN, USA.
Chwen-Yuen A ChenStanford University, Stanford, CA, USA.
Tracy KleinWashington State University, Vancouver, WA, USA.
Donovan MaustUniversity of Michigan, Ann Arbor, MI, USA.
Maryann Mazer-AmirshahiGeorgetown University, Washington, DC, USA.
Marcia MeccaYale School of Medicine, New Haven, CT, USA.
Deanna NajeraMedStar Emergency Physicians, Olney, MD, USA.
Chinyere OgbonnaKaiser Permanente San Jose Medical Center, San Jose, CA, USA.
Kiran F RajneeshThe Ohio State University, Columbus, OH, USA.
Elizabeth RollYukon Kuskokwim Health, Bethel, AK, USA.
Amy E SandersSunday Health, Vienna, VA, USA.
Brett SnodgrassBaptist Health System, Memphis, TN, USA.
Amy VandenBergUniversity of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Tricia WrightUniversity of California San Francisco, San Francisco, CA, USA.
Maureen BoyleAmerican Society of Addiction Medicine, Rockville, MD, USA.
Amanda DevotoAmerican Society of Addiction Medicine, Rockville, MD, USA.
Sarah Framnes-DeBoerAmerican Society of Addiction Medicine, Rockville, MD, USA.
Bethea KleykampUniversity of Maryland, Baltimore, MD, USA.
Janette NorringtonAmerican Society of Addiction Medicine, Rockville, MD, USA.
Dawn LindsayAmerican Society of Addiction Medicine, Rockville, MD, USA. dlindsay@asam.org.
Clinical Guideline Committee (CGC) Members
ASAM Staff and Contractors

Funding

FDA HHS U01 FD007804FDA HHS U01FD007804
6 · The paper itself

Abstract

descriptionThe American Society of Addiction Medicine (ASAM) has partnered with nine other medical societies and professional associations representing a wide range of clinical settings and patient populations to provide guidance on evidence-based strategies for tapering benzodiazepine (BZD) medication across a variety of settings.

methodsThe guideline was developed following modified GRADE methodology and clinical consensus process. The process included a systematic literature review as well as several targeted supplemental searches. The clinical practice guideline was revised based on external stakeholder review. RECOMMENDATIONS: Key takeaways included the following: Clinicians should engage in ongoing risk-benefit assessment of BZD use/tapering, clinicians should utilize shared decision-making strategies in collaboration with patients, clinicians should not discontinue BZDs abruptly in patients who are likely to be physically dependent and at risk of withdrawal, clinicians should tailor tapering strategies to each patient and adjust tapering based on patient response, and clinicians should offer patients adjunctive psychosocial interventions to support successful tapering.

Indexed as

BenzodiazepinesDrug TaperingSubstance-Related DisordersSubstance Withdrawal SyndromeHumansRisk AssessmentBenzodiazepinesBenzodiazepine taperingClinical guidelineShared decision-making

Identifiers

PMID40526204
PMCPMC12463801

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.