ReviewAnnals of biomedical engineering2025
Extracellular Matrix Viscoelasticity: A Dynamic Regulator of Cellular Behavior.
Review in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers.Science advances · 2026Article
- Linker Molar Mass-Driven Control over Supramolecular Network Relaxation and Architecture in BTA Hydrogels.Macromolecules · 2026Article
- AI-Resolved Protein Energy Landscapes, Electrodynamics, and Fluidic Microcircuits as a Unified Framework for Predicting Neurodegeneration.International journal of molecular sciences · 2026Review
- Manual therapy combined with core muscle training for chronic non-specific low back pain in sedentary individuals: a study protocol for a single-center randomized controlled trial.Frontiers in medicine · 2026Article
- Neurovascular Signaling at the Gliovascular Interface: From Flow Regulation to Cognitive Energy Coupling.International journal of molecular sciences · 2025Review
- Stabilization of adhesions controls F-actin architecture in mechanotransduction.Communications materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular matrix (ECM) is a three-dimensional network of polysaccharides and proteins that provides biochemical signals and structural rigidity to cells. In addition to structural support, the ECM provides dynamic mechanical properties such as viscoelasticity. Scientifically, viscoelasticity is the time-dependent response of materials under stress. Due to the viscoelastic behavior of the ECM, viscoelasticity plays a critical role in regulating and stimulating cellular behaviors such as adhesion, proliferation, differentiation, and migration, as well as tissue morphogenesis and remodeling. Scientific knowledge about viscoelasticity usually originates from materials science where physical parameters are well defined. Hence, understanding materials' physical/mechanical behaviors (especially biomaterials in biological contexts) and mathematical modeling related to viscoelasticity are important to achieve useful results. On the other hand, recent advances in the development of biophysical instruments for measuring viscoelasticity have revealed a strong link between material properties and physiological systems and have emerged as important diagnostic tools for investigating the viscoelastic behavior of cells and tissues. Therefore, this review, focusing on matrix viscoelasticity, explains the viscoelastic nature of cells/tissues, examines the impact of matrix viscoelasticity on cellular processes, reviews the role of engineered biomaterials in improving cellular behaviors, and finally discusses modern experimental techniques for measuring viscoelasticity at the cellular level.
Indexed as
Identifiers
40526357What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.