Evidence map›Paper›PMID 40526718›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Gut sulfide metabolism modulates behavior and brain bioenergetics.

Roshan Kumar, Delawrence J Sykes, Victor I Band, Megan L Schaller, Romel Patel, Victor Vitvitsky, Peter Sajjakulnukit, Rashi Singhal, Harrison K A Wong, Suchitra K Hourigan and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Power and poison: The intersections of HThe Journal of biological chemistry · 2025
    Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Roshan KumarDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-5372-8682
Delawrence J SykesDepartment of Biology, Berry College, Mount Berry, GA 30149.
Victor I BandClinical Microbiome Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Megan L SchallerDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-4347-8701
Romel PatelDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.
Victor VitvitskyDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-6251-6115
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-8556-7481
Rashi SinghalDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Harrison K A WongDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Suchitra K HouriganClinical Microbiome Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Fumito IchinoseDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.ORCID 0000-0003-4535-1632
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8332-3275

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Sulfide Oxidation and SignalingR35GM130183 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUMA V BANERJEE · 2019 to 2026
$3.6M
Understanding the mechanisms of iron addiction in colon cancerR01CA245546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2020 to 2024
$2.3M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
HHS | NIH (NIH) R01CA148828 R01CA245546HHS | NIH (NIH) R35GM130183NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA245546NCI NIH HHS R01 CA248160NIDDK NIH HHS P30 DK020572NIGMS NIH HHS R35 GM130183NIH HHS R01CA248160
6 · The paper itself

Abstract

The host-microbiome interface is rich in metabolite exchanges and exquisitely sensitive to diet. Hydrogen sulfide (H

Indexed as

Behavior, AnimalBrainEnergy MetabolismHydrogen SulfideQuinone ReductasesSulfidesAnimalsColonGastrointestinal MicrobiomeMaleMethionineMiceMice, Inbred C57BLMitochondriaHydrogen SulfideMethionineQuinone Reductasessulfide quinone reductaseSulfidesgut–brain axishydrogen sulfideketone bodymethioninesulfide quinone oxidoreductase

Identifiers

PMID40526718
PMCPMC12207524

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.