ArticleJournal of assisted reproduction and genetics2025
Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.
methodsThis retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled. Z-scores were calculated. Student's t-test, analysis of variance, Pearson's chi-squared (χ
resultsThe non-OHSS group included 27,337 women, while the OHSS group included 1,570 women (mild to moderate, 1,308; severe, 262). The OHSS group was significantly younger (34.86 ± 3.54 vs. 36.21 ± 3.58 years, p < 0.0001) and had significantly higher rates of primiparity, cesarean section, and polycystic ovary syndrome (88.98% vs. 82.89%, p < 0.0001; 75.8% vs. 65.75%, p < 0.0001; and 29.24% vs. 14.37%, p < 0.0001, respectively). OHSS was associated with a decreased incidence of low birth weight and with an increased incidence of macrosomia (adjusted odds ratio [95% confidence interval], 0.53 [0.38-0.72], p < 0.0001; and 1.83 [1.42-2.35], p < 0.0001). OHSS was associated with an increased incidence of transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS) (1.32 [1.02-1.71], p = 0.03; and 1.57 [1.30-1.91], p < 0.0001).
conclusionOHSS is associated with a decreased incidence of low birth weight and an increased incidence of macrosomia, TTN, and RDS.
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