Evidence map›Paper›PMID 40528126›Full record

ArticleCardiovascular toxicology2025

Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.

Julie A Griffith, Kallie J Schafner, Krista L Garner, Evan DeVallance, Sara E Lewis, Timothy R Nurkiewicz, Eric E Kelley, Brooke A Maxwell, William T Goldsmith, Elizabeth C Bowdridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie A Griffith *Department of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.ORCID http://orcid.org/0000-0002-3863-2172
Kallie J Schafner *Department of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.ORCID http://orcid.org/0009-0005-4761-8515
Krista L GarnerDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.
Evan DeVallanceDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.ORCID http://orcid.org/0000-0001-9444-0207
Sara E LewisDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.
Timothy R NurkiewiczDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.ORCID http://orcid.org/0000-0001-9105-970X
Eric E KelleyDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.
Brooke A MaxwellDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.
William T GoldsmithDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA.
Elizabeth C BowdridgeDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, 3076 Health Sciences Center North, PO Box 9229, Morgantown, WV, 26506-9229, USA. ebowdrid@hsc.wvu.edu.ORCID http://orcid.org/0000-0003-2183-1375

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Trupti Joshi · 2012 to 2026
$61.1M
Pre-doctoral Training in Systems ToxicologyT32ES032920 · NIEHS · WEST VIRGINIA UNIVERSITY · PI Timothy R Nurkiewicz · 2022 to 2026
$1.2M
NIGMS NIH HHS P20 GM103434NIH HHS K01 10029010NIH HHS P20 GM103434NIH HHS T32 ES032920
6 · The paper itself

Abstract

Pregnancy requires metabolic and endocrine changes that must occur to support fetal growth and development. Aberrations in these necessary modifications can impact maternal health and fetal growth. Exposure to toxicants during pregnancy can negatively affect fetal health and development, but studies on electronic cigarette (e-cig) exposure is limited. We hypothesized that maternal e-cig exposure during gestation leads to hormonal and redox imbalance and negatively impacts fetal development. Pregnant Sprague-Dawley rats were exposed to e-cig aerosols (1227 ± 131 mg/m

Indexed as

E-Cigarette VaporElectronic Nicotine Delivery SystemsFetal DevelopmentInhalation ExposureMaternal ExposurePlacentaProlactinVapingXanthine OxidaseAnimalsBiomarkersFemaleGestational AgeMaleMaternal-Fetal ExchangePregnancyBiomarkersE-Cigarette VaporProlactinXanthine OxidaseE-cigarettesGestationProlactinXanthine oxidase

Identifiers

PMID40528126
PMCPMC13058953

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.