ArticleScience China. Life sciences2025
Donor macrophage pyroptosis contributes to the development of aGVHD.
Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hematopoiesis could be improved by correcting aberrant bone marrow macrophages polarization in aplastic anemia patients.Science China. Life sciences · 2026Article
- SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease.Science China. Life sciences · 2026Article
- A living therapeutic platform for localized in situ modulation of macrophage pyroptosis ameliorates GVHD while preserving GVL.Journal of nanobiotechnology · 2026Article
- Serum Pyroptosis-Related Cytokines as Biomarkers for Diagnostic Assessment and Risk Stratification of Ocular Graft-versus-Host Disease: A Case-Control Study.Journal of inflammation research · 2025Article
- Exploring cell death mechanisms in liver transplantation: implications for graft survival.Frontiers in immunology · 2025Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyroptosis, a novel form of inflammation-related programmed cell death that often occurs in myeloid cells, plays an important role in multiple inflammatory diseases. Our previous study revealed macrophage dysfunction in acute graft-versus-host disease (aGVHD). However, whether macrophages undergo pyroptosis in aGVHD remains unknown. In our study, macrophage pyroptosis was observed in aGVHD mice. Additionally, serum IL-1β and IL-18 levels were increased in aGVHD patients. Almost all peritoneal macrophages in the aGVHD mice were derived from the donors. Less pathological damage and a longer survival time were observed in the mice that received purified T cells and bone marrow (BM) from AAV9-F4/80-GSDMD mice, indicating that macrophage pyroptosis in donor mice promoted the development of aGVHD. In addition, decreased proportions of CD69
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.