Evidence map›Paper›PMID 40528640›Full record

ArticleArchiv der Pharmazie2025

Hitting Two Birds With One Stone: Dual Modulation of Brain Carbonic Anhydrases and Histone Deacetylases Boosts Memory Consolidation.

Alessia Costa, Murat Bozdag, Gioele Renzi, Barbara Rani, Maria Beatrice Passani, Andrea Angeli, Gustavo Provensi, Fabrizio Carta, Claudiu T Supuran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessia CostaDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-3693-3019
Murat BozdagNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-5010-0355
Gioele RenziNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0009-0008-9109-030X
Barbara RaniDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Florence, Italy.
Maria Beatrice PassaniDepartment of Health Sciences, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Florence, Italy.
Andrea AngeliNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-1470-7192
Gustavo ProvensiDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-6182-6848
Fabrizio CartaNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-1141-6146
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-4262-0323

Funding

This study was supported by the European Union-Next Generation EU: Mission 4 Component 2, Investiment 1.5 Tuscany Health Ecosystem-THE; Spoke 8 CUP: B83C22003930001 (CTS); Mission 4 Component 2, Investiment 1.1 Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN) Code MUR: 2022BYZPFE-CUP: B53D23018540006 (G.P.) and Code MUR: P20223A9J3-CUP: B53D23031290001 (G.P.). The funders had no role in study design, data collection, data analysis, interpretation, or writing of the report.
6 · The paper itself

Abstract

Cognitive impairments, characterized by deficits in one or more cognitive domains, are common in several pathological conditions but remain inadequately addressed by available pharmacological treatments. Given the complexity and multifaceted mechanisms underpinning these deficits, multi-targeted directed ligands are emerging as promising strategies for developing more effective therapies. In this study, we reported the design, synthesis as well as In Vitro and Ex Vivo assessment of prototypic molecular scaffolds that activate the carbonic anhydrase (CA; EC 4.2.1.1) and inhibit the histone deacetylase (HDAC; EC 3.5.1.98) metalloenzymes. By using the novel object recognition paradigm, we found that these compounds significantly enhanced memory consolidation at doses 10 times lower than single-target reference compounds. Taken together, these results suggest that the dual modulation of CA and HDAC activities by means of a single hybrid molecular entity represents an innovative approach for the management of cognitive symptoms associated with neurodegenerative, neurodevelopment, and psychiatric disorders.

Indexed as

BrainCarbonic Anhydrase InhibitorsCarbonic AnhydrasesHistone Deacetylase InhibitorsHistone DeacetylasesMemory ConsolidationAnimalsDose-Response Relationship, DrugHumansMaleMiceMolecular StructureStructure-Activity RelationshipCarbonic Anhydrase InhibitorsCarbonic AnhydrasesHistone Deacetylase InhibitorsHistone Deacetylasescarbonic anhydrase activatorscognitiond‐phenylalaninehistone deacetylase inhibitorsmetalloenzymesmultitarget ligands

Identifiers

PMID40528640
PMCPMC12174897

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.