Evidence map›Paper›PMID 40528796›Full record

Trial reportESC heart failure2025

HEART Camp Connect-Promoting adherence to exercise in adults with heart failure with preserved ejection fraction.

Windy W Alonso, Sara E Bills, Scott W Lundgren, Steven J Keteyian, Joseph Norman, Alfred L Fisher, Cheng Zheng, Kevin A Kupzyk, Fernando A Wilson, Tiffany J Dudley and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Windy W AlonsoCollege of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID https://orcid.org/0000-0002-8711-6756
Sara E BillsCollege of Allied Health Professions, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Scott W LundgrenDivision of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Steven J KeteyianHenry Ford Health System, Detroit, MI, USA.
Joseph NormanCollege of Allied Health Professions, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Alfred L FisherDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Cheng ZhengDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Kevin A KupzykCollege of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Fernando A WilsonSchool of Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Tiffany J DudleyCollege of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Bunny J PozehlCollege of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Funding

HEART Camp Connect: Promoting Adherence to Exercise in Adults with Heart Failure with Preserved Ejection FractionR01HL163288 · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2025 to 2025
$672k
National Heart Lung and Blood Institute of the National Institutes of Health R01HL163288NHLBI NIH HHS R01 HL163288
6 · The paper itself

Abstract

aimsMost adults with stable heart failure are safe to exercise at a moderate intensity for 150 min/week. Regular participation in exercise may improve outcomes in adults with heart failure with preserved ejection fraction (HFpEF). Few adults with HFpEF initiate and sustain long-term exercise. To promote exercise adherence in adults with HFpEF, we developed the Heart Failure Exercise and Resistance Training (HEART) Camp Connect intervention that is tested in this clinical trial. This trial tests our central hypothesis that theory-informed coaching strategies delivered virtually will promote long-term adherence to exercise in adults with HFpEF and drive clinically meaningful, and cost-effective improvements in physiological and patient-reported outcomes. Our aims are to (a) evaluate the effects of virtual and in-person exercise and coaching on long-term adherence, (b) determine a benchmark of minutes of moderate intensity exercise associated with health status as related to key biobehavioural outcomes, (c) examine behaviour change theory-defined constructs as mediators of exercise adherence and (d) evaluate intervention costs.

methodsThis 18 month, three-group, repeated measures randomized controlled trial is enrolling 300 adults with HFpEF. Participants are randomized to enhanced usual care (EUC), virtual coaching, or in-person coaching. Our intervention applies coaching strategies, informed by behaviour change theories, in one-on-one and group settings weekly for 12 months. Our objective is to compare the effects of each delivery method to the other and EUC on exercise adherence (defined as ≥ 120 min of moderate intensity exercise/week) at 12 months (primary endpoint) and 18 months (sustainability endpoint). Secondary outcomes include minutes of moderate intensity exercise needed to drive minimal clinically important differences in health status, biomarkers, patient-reported symptoms and cost. Behaviour change theory-defined constructs (e.g., self-efficacy and outcome expectations) will be tested as mediators of exercise adherence.

resultsWe expect that virtual coaching is equally as efficacious and more cost effective at promoting exercise adherence as in-person coaching. Effects on exercise adherence may be mediated by theory-defined constructs. We also expect to identify a threshold for minutes of moderate intensity exercise to potentially serve as an adherence benchmark in adults with HFpEF, one that may differ from the 120 min of exercise in our current definition.

conclusionsThese findings could shift the paradigm of exercise coaching in HF towards virtual delivery and increase the generalizability and reach of exercise training. This is especially important for adults with HFpEF as they are excluded from Medicare reimbursement for traditional cardiopulmonary rehabilitation.

Indexed as

ExerciseExercise TherapyHeart FailurePatient ComplianceStroke VolumeAgedFemaleHumansMaleMiddle Agedadherenceexerciseheart failureheart failure with preserved ejection fractionpatient‐reported outcomessymptoms

Identifiers

PMID40528796
PMCPMC12450787

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.