Evidence map›Paper›PMID 40529097›Full record

ArticleACS medicinal chemistry letters2025

Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation.

Shin-Young Park, Dang Pham, Param Shukla, Justin Edward, Reshmi John, Addison Li, Michael Hadjiargyrou, Mattia Mori, Elisa Zuccarello, Ottavio Arancio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shin-Young ParkDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Dang PhamDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Param ShuklaDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Justin EdwardDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Reshmi JohnDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Addison LiDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Michael HadjiargyrouDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.ORCID https://orcid.org/0000-0003-2398-1254
Elisa ZuccarelloTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York 10032, United States.ORCID https://orcid.org/0000-0001-8489-503X
Ottavio ArancioTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York 10032, United States.ORCID https://orcid.org/0000-0001-6335-164X
Jole FioritoDepartment of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York 11568, United States.ORCID https://orcid.org/0000-0001-6106-3556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphodiesterase 5 (PDE5) inhibitors have been suggested as new treatments for Alzheimer's disease (AD) and other conditions such as cancer and cardiovascular diseases. Utilizing the widespread presence of the indole moiety in biomolecules and drugs, previously synthesized quinoline and naphthyridine compounds were modified into novel indole-containing PDE5 inhibitors. Replacing the amine with an amide group led to identifying a potent analogue, compound

Indexed as

Alzheimer’s DiseaseIndole-containing MoleculesPDE5PDE5 Inhibitors

Identifiers

PMID40529097
PMCPMC12169455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.