ArticleInfection and drug resistance2025
Pan-Genome-Wide Association Study Identifies Genetic Factors Associated with the Pathogenicity of Invasive Serotype 19F Streptococcus Pneumoniae.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Convergence of Antimicrobial Resistance and Virulence inMicroorganisms · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: We compared the genomic profiles of 42 invasive and 162 noninvasive strains from children's respiratory tracts and employed pan-genome-wide association methods to elucidate the origins of genetic variation. Results: Significant gene presence variability was observed between invasive and noninvasive strains, suggesting a genetic basis for their pathogenicity differences. Invasive 19F strains demonstrated enhanced adhesion in co-culture experiments with human epithelial cells, with adhesion abilities correlating with the presence of specific genes. Despite high non-susceptibility to common antibiotics across all strains, no significant differences in antimicrobial susceptibility patterns were found between invasive and noninvasive groups. Conclusion: Although genomic differences within serotype 19F were relatively minor, invasive and noninvasive strains exhibited significant differences in adherence and invasiveness in the host microenvironment. While the underlying regulatory mechanisms remain uncertain, genetic differences play a crucial role in determining the invasiveness of
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