ReviewFrontiers in nutrition2025
The role of vitamin D in sleep regulation: mechanisms, clinical advances, and future directions.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Encapsulated Leptin-Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association between preoperative 25-hydroxyvitamin D3 levels and postoperative delirium in pediatric patients undergoing general anesthesia for laparoscopic surgery: a single-center retrospective study.Translational pediatrics · 2026Article
- Vitamin D as a Regulator of the Biological Clock-Implications for Circadian-Metabolic Dysregulation.International journal of molecular sciences · 2026Review
- Indoor Employment as a Factor Associated with Vitamin D Levels in Obstructive Sleep Apnoea Syndrome.Medicina (Kaunas, Lithuania) · 2026Article
- Effect of vitamin D supplementation on fatigue and mood among perimenopausal women.Bioinformation · 2026Article
- The mediating role of sleep quality in the association between inflammatory disease activity and health-related quality of life in rheumatoid arthritis.Frontiers in medicine · 2026Article
- Unveiling the relationship between dietary patterns and sleep quality: cross-sectional evidence from university students in Jinan city.Frontiers in nutrition · 2026Article
- Vitamin D3 Improves Hypothalamic-Pituitary-Adrenal Axis Function, Immunological Responses, and Gut Dysbiosis in Sleep Desynchrony.Brain and behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D, an essential neuroendocrine regulator, exhibits a significant dose-dependent association with various sleep disorders according to epidemiological evidence, and plays a multifaceted and critical role in sleep regulation. This review summarizes the molecular mechanisms, clinical applications, and future directions of vitamin D in sleep regulation. Vitamin D may influence sleep through multiple molecular pathways, including modulation of neurotransmitter systems, maintenance of circadian rhythms, and neuroimmune regulation. Clinical trials have demonstrated that vitamin D supplementation significantly improves sleep quality, particularly in special populations such as the elderly and pregnant women. However, challenges persist in optimizing individualized treatment regimens, developing novel drug delivery systems, and evaluating long-term efficacy. The integration of multi-omics analyses and artificial intelligence offers innovative solutions to these challenges. Future research should focus on elucidating the precise molecular mechanisms of vitamin D in sleep regulation, refining personalized therapeutic strategies, and advancing innovative delivery systems to enhance the prevention and treatment of sleep disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.