Evidence map›Paper›PMID 40529475›Full record

ReviewJID innovations : skin science from molecules to population health2025

Cutaneous and Gut Dysbiosis in Alopecia Areata: A Review.

Nicole E Burma, Michele L Ramien

Abstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicole E BurmaDivision of Dermatology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Michele L RamienDivision of Dermatology, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata (AA) is a common, immune-mediated nonscarring alopecia. Breakdown of immune privilege combined with local immune cell infiltration is central to the development of AA; yet, the instigating factors causing immune dysregulation remain elusive. Recent attention has focused on the microbiome in AA, where alterations to the usual composition of healthy microorganisms is observed. This review examines the current evidence for bacterial dysbiosis affecting the scalp and gut of patients with AA and summarizes the potential influence of altered microbial composition on immune dysregulation in AA. Although the literature supports changes to the bacterial composition of patients with AA, a causal link between microbial dysbiosis and AA pathogenesis remains to be established.

Indexed as

Alopecia areataDysbiosisImmune privilegeMicrobiome

Identifiers

PMID40529475
PMCPMC12173129

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.