ReviewRSC medicinal chemistry2025
Five years of research on 2,4-thiazolidinediones as anticancer agents: medicinal chemistry insights (2020-2024).
Review in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2,4-Thiazolidinediones (2,4-TZDs) are a class of heterocyclic compounds traditionally recognized for their antidiabetic activity, particularly as peroxisome proliferator-activated receptor gamma (PPARγ) agonists. However, in recent years, they have emerged as promising anticancer scaffolds due to their ability to influence key molecular pathways involved in tumorigenesis, including cell proliferation, apoptosis, angiogenesis, and metastasis. The structural flexibility of the 2,4-TZD core-especially at the C-5 position-makes it highly amenable to derivatization, offering opportunities to fine-tune bioactivity and selectivity. This review presents a focused evaluation of 2,4-TZD derivatives reported between 2020 and 2024, emphasizing structure-activity relationship (SAR) studies and their implications for anticancer drug design. We discuss how various substituent modifications influence cytotoxic potency and target selectivity. In addition, we explore the molecular mechanisms underlying the anticancer activity of selected 2,4-TZD derivatives, along with an overview of their pharmacological relevance. This compilation aims to serve as a valuable resource for medicinal chemists and drug discovery researchers working on next-generation 2,4-TZDs as targeted anticancer therapeutics.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.