ArticleCureus2025
Therapeutic Efficacy of a 1% Metformin Chip as an Adjunct to Nonsurgical Periodontal Therapy: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Efficacy of metformin as an adjunct in periodontitis: A systematic analysis.Journal of Taibah University Medical Sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the clinical and microbiological effectiveness of a 1% metformin biodegradable chip as an adjunct to scaling and root planing (SRP) in patients diagnosed with stage II, grade B periodontitis. MATERIALS AND
methodsA randomized, double-blind, placebo-controlled, parallel-group, single-center trial was conducted in systemically healthy patients diagnosed with stage II, grade B periodontitis. Patients were randomly assigned to two groups: the test group (SRP + 1% metformin chip) and the control group (SRP + placebo chip). Clinical and microbiological parameters were evaluated at baseline and three months post-treatment. These included plaque index (PI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD), clinical attachment level (CAL), and microbial load, which was assessed by quantifying the colony-forming units (CFUs) of
conclusionThe adjunctive use of a 1% metformin chip with SRP significantly enhances clinical outcomes and reduces microbial load, supporting its potential as an effective therapeutic approach for the management of periodontitis.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.