ArticleFrontiers in plant science2025
Integrated transcriptomic and metabolomic analyses provide new insights into alkaline stress tolerance in
Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Molecular networks and signaling pathways governing abiotic stress tolerance in cotton: advances and perspectives.Functional & integrative genomics · 2026Review
- Multiomics Profiling Unveils Key Genes and Metabolites Involved in the Salt Tolerance ofGenes · 2025Article
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Authors and funding
11 authors.
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Abstract
Introduction: Cotton, one of the most important economic crops worldwide, has long been bred mainly for improvements in yield and quality, with relatively little focus on salt-alkali resistance. Methods: In this study, transcriptomic and metabolomic sequencing were performed on Results: The results of sample clustering, principal component analysis (PCA), and the number of differentially expressed genes (DEGs) revealed that 12 hours and 24 hours were the periods during which upland cotton presented the strongest response to salt stress, with flavonoid biosynthesis and alpha-linolenic acid metabolism playing significant roles during this time. A total of 6,610 DEGs were identified via comparison to the 0 h time point, including 579 transcription factors (TFs) that were significantly enriched in pathways such as flavonoid biosynthesis, the cell cycle, the cytochrome P450 pathway, phenylalanine metabolism, phototransduction, and alpha-linolenic acid metabolism. Through ultrahigh-performance liquid chromatography-MS (UPLC-MS), 4,225 metabolites were identified, and 1,684 differentially accumulated metabolites (DAMs) were identified by comparison to the levels at 0 h. A joint analysis of RNA-seq and metabolomic data revealed that the flavonoid biosynthesis and alpha-linolenic acid metabolism pathways play key roles in the response of Conclusion: In conclusion, our study provides a theoretical foundation for understanding the molecular mechanisms underlying alkali tolerance in cotton and offers new gene resources for future research.
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