ReviewRSC advances2025
Therapeutic potential of betaine and its derivatives in cancer treatment: a comprehensive review.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The effect of beetroot juice (BRJ) supplementation on exercise-induced muscle damage (EIMD): a systematic review and dose-response meta-analysis of randomized controlled trials.Annals of medicine and surgery (2012) · 2026Article
- Plant-Derived Natural Compounds and Nrf2-Centered Redox Signaling in Intracerebral Hemorrhage: Evidence Grading, Mechanistic Boundaries, and Translational Challenges.Antioxidants (Basel, Switzerland) · 2026Review
- Immunotherapy for depression: targeting cytokine pathways in major depressive disorder.Psychopharmacology · 2026Review
- Diet-Driven Epigenetic Alterations in Colorectal Cancer: From DNA Methylation and microRNA Expression to Liquid Biopsy Readouts.Biomedicines · 2026Review
- Nutraceutical and Antitumoral Potential ofFoods (Basel, Switzerland) · 2026Article
- Exogenous Glycine Betaine Decreases Cell Proliferation and Induces Apoptosis in Human Colorectal Adenocarcinoma HT-29 Cells.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive natural compounds and their analogues play a significant role in the treatment of fatal diseases such as malaria, pneumonia, hepatic disorders, heart diseases and various types of cancer. Existing chemoprotective treatments for different types of cancer employ numerous natural compounds from medicinal plant extracts, fruits, vegetables, herbs, microorganisms and marine life. One of these bioactive compounds is betaine, which is a natural constituent with remarkable antioxidant and anticancer properties. The betaine scaffold and its derivatives have demonstrated suppressive effects on the progression, metastasis and angiogenesis of cancer cells. Although multiple studies have reported that betaine and its derivatives demonstrate remarkable efficiency in treating cancer or preventing tumor growth, a review summarizing the literature on this important anticancer agent is lacking to date. Thus, the present review article provides a detailed overview of the reported literature on the use of betaine and its derivatives in the prevention of different types of cancers and discusses the inhibitory activities of betaine against various types of tumorigenesis and its mechanism of action. The synergistic effects of betaine with phytochemicals and nanostructure-based medication delivery systems and its molecular modification for lowering the risk of cancer in humans are also discussed in detail.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.