ArticleJournal of the American Heart Association2025
Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundWhile peripheral artery disease care for claudication aims to improve health status (symptoms, physical function, and quality of life), health status trajectories remain unclear. We aimed to determine health status trajectories and explore baseline factors associated with treatment nonresponsiveness.
methodsData were derived from the PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) registry of patients with claudication symptoms presenting to vascular specialty clinics across the United States, Australia, and Netherlands. The Peripheral Artery Questionnaire was used to measure the health status at baseline and 3, 6, and 12 months. Latent trajectory modeling enabled the classification of patients into latent Peripheral Artery Questionnaire trajectory subgroups over 12 months. These subgroups were categorized as "responsive" or "nonresponsive," depending on whether the 12-month increase in mean Peripheral Artery Questionnaire score was greater than or equal to the clinically meaningful threshold of 10 or not, respectively. Sequential hierarchical multivariable logistic regression assessed baseline factors associated with a nonresponsive versus responsive trajectory.
resultsThe cohort was composed of 1204 patients (62.5% men and aged 67.5±9.4 years). Five latent trajectory subgroups were identified: consistently high (33.3%), high maintained (8.1%), high transient (12.9%), moderate maintained (33.2%), and consistently low response (12.5%) with mean Peripheral Artery Questionnaire improvements of +16.8, +59.4, +7.6, +24.0, and +8.6, respectively. Nonresponsive clinical trajectory was associated with prior cerebrovascular accident, sleep apnea, alcohol use disorder, and worse depressive symptoms.
conclusionsIndividuals with claudication display heterogenous recovery trajectories. Roughly 25% experienced no health status response at 12 months after treatment, which was associated with medical and psychosocial factors. Further emphasis should be placed on a biopsychosocial model of peripheral artery disease care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.