Evidence mapPaperPMID 40530899Full record

ArticleJournal of medicinal chemistry2025

Fluorescent Isostere (

Stefano Sainas, Elena Martino, Claudio Garino, Paola Circosta, Anna Luganini, Marta Giorgis, Francesco Bavo, Marco Piccinini, Cristina Ramondetti, Marta Alberti and 5 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefano SainasDepartment of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy.ORCID 0000-0001-5010-8536
Elena MartinoDepartment of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy.
Claudio GarinoDepartment of Chemistry, University of Torino, Via Pietro Giuria 7, Torino 10125, Italy.ORCID 0000-0002-7854-6076
Paola CircostaDepartment of Clinical and Biological Sciences, University of Torino, Regione Gonzole 10, Orbassano, Torino 10043, Italy.ORCID 0000-0001-8251-6905
Anna LuganiniDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino 10123, Italy.
Marta GiorgisDepartment of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy.ORCID 0000-0002-3282-1220
Francesco BavoDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.ORCID 0000-0003-3797-0900
Marco PiccininiDepartment of Oncology, University of Torino, Via Michelangelo 27/B, Torino 10125, Italy.ORCID 0000-0003-2287-0704
Cristina RamondettiDepartment of Oncology, University of Torino, Via Michelangelo 27/B, Torino 10125, Italy.ORCID 0000-0002-0501-5696
Marta AlbertiDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara 28100, Italy.ORCID 0000-0003-3827-7243
Riccardo MiggianoDepartment of Pharmaceutical Sciences, University of Piemonte Orientale, Via G. Bovio 6, Novara 28100, Italy.
Giorgio GribaudoDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, Torino 10123, Italy.
Donatella BoschiDepartment of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy.ORCID 0000-0003-4929-4460
Bente FrølundDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen DK-2100, Denmark.ORCID 0000-0001-5476-6288
Marco Lucio LolliDepartment of Drug Science and Technology. University of Torino, Via Pietro Giuria 9, Torino 10125, Italy.ORCID 0000-0002-3030-3163

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent probes targeting proteins are used to investigate biological processes, requiring strong binding affinity and favorable fluorescence. In this study, we present the first

Indexed as

Antineoplastic AgentsCarboxylic AcidsDrug DesignEnzyme InhibitorsFluorescent DyesAntiviral AgentsCell Line, TumorHumansProof of Concept StudyStructure-Activity RelationshipAntineoplastic AgentsAntiviral AgentsCarboxylic AcidsEnzyme InhibitorsFluorescent Dyes

Identifiers

PMID40530899
PMCPMC12257544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.