SynthesisIrish journal of medical science2025
Preoperative proteinuria as a novel biomarker for predicting postoperative renal insufficiency after nephrectomy for renal cell carcinoma: a systematic review and meta-analysis.
Synthesis in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIdentifying reliable predictors of postoperative renal insufficiency (PRI) following partial or radical nephrectomy for renal cell carcinoma (RCC) is critical for optimizing perioperative management.
methodsWe systematically searched MEDLINE, Cochrane Library, and Embase up to March 20, 2025, to identify cohort studies that evaluated the association between preoperative proteinuria and PRI. We calculated pooled odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were stratified by study design (prospective vs. retrospective) and surgical modality (partial vs. radical nephrectomy).
resultsSix cohort studies involving 3124 patients were included. Preoperative proteinuria was significantly associated with an increased risk of PRI (OR = 2.69, 95% CI 1.48-4.89; I
conclusionPreoperative proteinuria is significantly associated with an elevated risk of PRI in patients undergoing nephrectomy for renal cell carcinoma. These findings emphasize the need to incorporate proteinuria assessment into preoperative risk evaluations to improve patient counselling and perioperative management. Future high-quality prospective studies, particularly multicenter investigations with standardized protocols, are essential to confirm these associations and explore the pathophysiological mechanisms underlying proteinuria-related renal functional decline.
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