ArticleMolecular neurobiology2025
Unveiling Moxibustion's Impact on AD Mice Learning and Memory: Role of Mitochondrial Respiratory Chain Complex I Subunit in the Hippocampus.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The impact of moxibustion on brain function in vascular dementia: a neuroimaging study involving amplitude of low-frequency fluctuations and functional connectivity.Frontiers in neurology · 2025Trial
- Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease.Animal models and experimental medicine · 2026Article
- Transcriptomic Profiling in Aged Mice Reveals an Association Between Sevoflurane Anesthesia and Neurocognitive Dysfunction.Cellular and molecular neurobiology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by significant impairment in energy metabolism. Our previous studies have demonstrated that moxibustion can ameliorate cognitive dysfunction by enhancing brain energy metabolism in individuals with AD, yet its fundamental mechanism remains incompletely understood. In this study, spatial transcriptomics, biochemical assays, and transmission electron microscopy were utilized to identify differentially expressed genes related to metabolism and their functions, as well as to determine the key metabolic genes influenced by moxibustion. Moxibustion significantly promote spatial learning and memory ability, while reducing the production of hippocampal pathological markers in APP/PS1 mice. Respiratory chain complex I may play an important role in regulating energy metabolism in the hippocampus during moxibustion. Additionally, moxibustion also elevated co-expression of PSD95/SYN, which exhibited a positive correlation with energy metabolism. Thus moxibustion has the potential to improve energy metabolism and synaptic plasticity in the hippocampus, subsequently ameliorating learning and memory impairments.
Indexed as
Identifiers
40531365What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.