Evidence map›Paper›PMID 40531438›Full record

ArticleAMB Express2025

Engineered Prx-LCA2 fusion protein restores oxidative skin damage via enhanced intracellular peroxidase delivery.

Di Liu, Yafen Zhan, Jiaqi Qu, Hongping Qiao, Na Li, Yeli Zhang, Xiaoying Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Di Liu *College of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China. diliu_tynu@163.com.
Yafen Zhan *College of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.
Jiaqi QuCollege of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.
Hongping QiaoCollege of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.
Na LiCollege of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.
Yeli ZhangCollege of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.
Xiaoying WuCollege of Biological Sciences and Technology and Center for Veterinary Medicine, Taiyuan Normal University, Jinzhong, 030619, Shanxi, China.

Funding

Fundamental Research Program of Shanxi Province 20210302123317
6 · The paper itself

Abstract

This study developed a novel antioxidant fusion protein Prx-LCA2 by conjugating peroxidase Prx with the LCA2 carrier derived from Escherichia coli heat-labile enterotoxin, aiming to achieve efficient intracellular delivery for oxidative damage remediation. The fusion protein Prx-LCA2 was successfully expressed in E. coli and purified. Fluorescence labeling demonstrated efficient cellular internalization of the fusion protein. In vitro, H

Indexed as

LCA2 protein carrierOxidative stressPeroxidase activitySkin antioxidant defense

Identifiers

PMID40531438
PMCPMC12177121

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.